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Pharmacodynamics, Isoconazole is a synthetic imidazole derivative. Travocort has a broad antifungal and antibacterial spectrum of action. Acts fungicidal and bactericidal. Suppresses the synthesis of ergosterol of the membranes of fungal cells, causing its death, blocks the synthesis of bacterial proteins. It is active against dermatophytes (Trichophyton spp., Microsporum spp., Epidermophyton spp., Etc.), molds, yeast and yeast-like fungi (Candida spp., Pityrosporum orbiculare / ovale (Malassezia furfur), Corynebacterium - the causative agent of gram-positive bacteria and minut spp., Streptococcus spp. Diflucortolone valerate - GCS for local use. It has anti-inflammatory, anti-exudative, anti-allergic and antipruritic effects. Pharmacokinetics, Pharmacokinetic studies have not been conducted. |
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Side effects, Travocort is generally well tolerated, even when applied to sensitive skin. In rare cases, skin irritation and allergic reactions may develop. Considering that the composition of the drug Travocort includes diflucortolone, when the cream is applied on extensive surfaces (more than 10% of the skin surface) for a long time (more than 4 weeks) and / or when using an occlusive dressing, side effects typical for GCS may appear: skin atrophy , telangiectasia, striae, acne-like dermatitis, perioral dermatitis, hypertrichosis, as well as systemic side effects (suppression of the function of the hypothalamic-pituitary-adrenal system). It is impossible to completely exclude the development of side effects (for example, a decrease in the function of the adrenal cortex) in newborns whose mothers received long-term treatment during pregnancy or lactation or applied the drug to extensive body surfaces. How to take, course of administration and dosage Outwardly Travocort is applied in a thin layer to the affected skin and rubbed lightly 2 times a day (morning and night). After regression of the inflammatory process, treatment with Travocort should be discontinued and therapy with Travogen cream, which does not contain GCS, should be continued. This is important when applying the drug to the genital area and inguinal folds.The maximum duration of treatment is 2 weeks. |
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