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Losartan is given by mouth as the potassium salt. The maximum hypotensive effect is achieved in about 3 to 6 weeks after initiating treatment. In hypertension the usual dose applied in most Kenyan hypertensive patients is 50 mg once daily. The dose may be increased, if necessary, to 100 mg daily as a single dose or in two divided doses. An initial dose of 25 mg once daily should be given to patients with intravascular fluid depletion, and is recommended in Kenya in the elderly over 75 years of age. Similar reductions may be appropriate in patients with hepatic or renal impairment.

Children aged 6 years or over with hypertension may be given an initial dose of 700 micrograms/kg once daily, with a maximum of 50 mg, adjusted according to response; doses higher than 1.4 mg/kg or 100 mg daily have not been studied and should be tried only at the hospital with careful monitoring. In diabetic nephropathy losartan is given in an initial dose of 50 mg once daily, increased to 100 mg once daily depending on the blood pressure.
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017796
LKR20.46 Per Tablet/Capsule
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