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Pharmacology: Pharmacodynamics: Gliclazide reduces blood glucose by stimulating insulin secretion from the βcells in the islets of Langerhans.
In type 2 diabetics, gliclazide restores the first peak of insulin secretion in response to glucose and increases the second phase of insulin secretion.
A significant increase in insulin response is seen in response to stimulation induced by a meal or glucose.
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