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| Structure and Composition: Ointment for external application 1 g contains: betamethasone dipropionate 0.643 mg (Equivalent to Betamethasone 0.5 mg). calcipotriol monohydrate 0.052 mg (Corresponding to 0.05 mg of calcipotriol). Excipients: liquid paraffin polyoxypropylene-15-stearyl ether alpha-tocopherol White soft paraffin in tubes of aluminum or PE 15, 30 or 60 grams in paper cartons 1 tube. Description pharmaceutical form: Homogeneous ointment from almost white to pale yellow. |
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| Description of the pharmacological actions: Calcipotriol – a synthetic analogue of the active metabolite of vitamin D. It is the inhibition of proliferation of keratinocytes and accelerates their morphological differentiation. Betamethasone – GCS for external use has a local anti-inflammatory, antipruritic, vasoconstrictive and immunosuppressive effect, but the exact mechanisms of the anti-inflammatory actions of topical corticosteroids is unclear until the end. The use of occlusive dressings increases the effect of topical corticosteroids, be Pharmacokinetics: In applying the drug Daivobet calcipotriol and betamethasone absorption through intact skin is less than 1%. When applying the drug on the psoriatic plaques and under occlusive dressings increases the absorption of topical corticosteroids. Since the skin creates a depot preparation, its elimination from the skin occurs within a few days. Betamethasone is metabolised in the liver and kidneys to form glucuronides and sulfoefirov, excretion is carried out through the intestines and kidneys.cause it increases their penetration into the dermis. |
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