Each film-coated tablet contains estradiol 2 mg for the first 14 days of a cycle (orange tablets). For the 2nd part of 14 days of a cycle of 28 days, 1 film-coated tablet contains estradiol 2 mg and dydrogesterone 10 mg (yellow tablets).
Estradiol is the primary estrogen and the most active of the ovarian hormones.
The endogenous estrogens are involved in certain functions of the uterus and accessory organs, including the proliferation of the endometrium and the cyclic changes in the cervix and vagina.
Estrogens are known to play an important role for fat metabolism and bone; thus, maintain bone mass, and has preventive effect on the incidence of osteoporotic fractures.
Oral administration of estrogens can have a beneficial effect on the metabolism of lipids and lipoproteins.
Treatment with estradiol/dydrogesterone combinations for up to 24 months resulted in a significant decrease in LDL cholesterol levels and a significant increase in HDL cholesterol.
riglyceride levels were raised overall but usually remained within the normal range.
Furthermore, estrogens also affect the autonomic nervous system and may have indirect positive psychotropic actions.
Dydrogesterone is an orally active progestogen having an activity comparable to parenterally administered progesterone.